GTA V is kinda broken for me now game starts just fine, no stutter and high fps in the 80s, then after about 10 mins the fps just tanks, loads of stutter, fps go to around 25 with both cards at 100% usage then more offen than not it'll crash.
Two cards runs pretty well for me, but there is always a little stutter when entering new areas when driving, really spoils it for me. I find that playing this game with one gpu and FreeSync enabled is the way to go for the best possible smoothness. I think it's just this game has pushed the API to the absolute limit.
Here's a trick you can try though. Start the game and get in a car, then press alt + enter to go into Windowed mode and then alt + enter to go back to full screen mode. Does that improve things? Seems to help smooth the game out a bit for me when using two gpu's.